Jiang et al. [46] reported that, in both total-region and normal-region analyses, patients exhibiting larger areas and higher densities of tertiary lymphoid structures (TLSs) experienced significantly improved OS, particularly among non-elderly individuals (p = 0.044), males (p = 0.002), stage III colorectal cancer cases (p < 0.001), patients with low carcinoembryonic antigen levels (p = 0.022), and those with both high and low carbohydrate antigen 19-9 levels (p = 0.045 and p = 0.036, respectively). The gene discussed is CEACAM5; the disease is colorectal cancer.