TP53 and neoplasm: Pathway enrichment analysis of the hypermethylated genes revealed involvement in tumor suppressor pathways such as P53 feedback loops and TGF-beta signaling [2,39,40,41,42] oncogenic pathways including P38 MAPK and Ras pathways [43] and immune signaling pathways like IFN-gamma signaling [44,45] (Figure 4B).