IFI27 is transcribed as a type I interferon (IFN-I) stimulated gene (ISG) mediated by the STAT1/STAT2/IRF9 complex, and activation of the interferon-alpha receptor and increased mRNA levels of ligands and receptors in the TGFB pathway play important roles in the PDAC tumor microenvironment [12]. The gene discussed is IFI27; the disease is neoplasm.