A retrospective study of tumor tissues and CSF samples from 23 glioblastoma patients with metastatic dissemination to the spinal cord or medulla oblongata demonstrated significantly reduced expression levels of several STC-1-regulating microRNAs as well as increased STC-1 mRNA expression compared to those without metastasis, implicating a possible association for STC-1 in promoting glioblastoma CSF dissemination [58]. The gene discussed is STC1; the disease is glioblastoma.