PIK3CA and neoplasm: Other mutations of interest, such as PIK3CA (E545K, NG_012113.2:g.74781G>A) and ARID1A (R1324L, NG_011536.1:g.51312G>T), typically observed in noncervical cancers such as colorectal or endometrial tumors, were found; these variants may reflect shared pathways (e.g., APOBEC-driven mutagenesis) across tumor types.