Additionally, the upregulation of ICM, such as PD1, CTLA4, LAG3, TIM3, KLRG1, TIGIT, and 2B4 on T-cells, contributes to T-cell exhaustion and impaired functionality, correlating with poor prognosis and reduced overall survival in AML patients [26,27,28,29]. The gene discussed is HAVCR2; the disease is acute myeloid leukemia.