Our data show and confirm [12,30,33] that higher frequencies of CTLA4- and PD1-expressing T-cells are found in uncultured AML patients’ samples compared to healthy blood donors’ samples, with high proportions of patients presenting with more than 20% of CTLA4 or PD1 expressing T-cells (Figure 1B). The gene discussed is CTLA4; the disease is acute myeloid leukemia.