Specifically, the computed influence of anti-Smith antibodies (ADS) (p < 0.004) and low C3/C4 (p < 0.03) discriminated significantly in favor of SLE+ over UCTD, while proteinuria (p < 0.009) and non-scarring alopecia (NSA) (p < 0.015) had statistically greater weighted genAI prevalences in UCTD than SLE+. This evidence concerns the gene C3 and systemic lupus erythematosus.