Among these variables, capsular irregularity or bulge, neurovascular bundle asymmetry, CLL ≥ 1.5 cm, SVI on MRI, tumor size ≥ 14.25 mm on MRI, EPE grade ≥ 1, EPE grade ≥ 2, overt EPE on PET; SUVmax ≥ 13.84, SUVmean ≥ 7.195, PSMA-TV ≥ 1.395 cm3 were statistically significant predictors of EPE (Table 3). This evidence concerns the gene FOLH1 and B-cell chronic lymphocytic leukemia.