The following multivariate models were compared: (1) EPE grade ≥ 2 and ISUP grade ≥ 3; (2) EPE grade ≥ 2 and ISUP grade ≥ 3 and tumor size ≥ 14.25 mm; (3) overt EPE on PET and SUVmax ≥ 13.84 and PSMA-TV ≥ 1.395 cm3; (4) EPE grade ≥ 2 and SUVmax ≥ 13.84; (5) EPE grade ≥ 2 and PSMA-TV ≥ 1.395 cm3; (6) EPE grade ≥ 2 and ISUP grade ≥ 3 and SUVmax ≥ 13.84; (7) EPE grade ≥ 2 and ISUP grade ≥ 3 and PSMA-TV ≥ 1.395 cm3; (8) EPE grade ≥ 2 and ISUP grade ≥ 3 and tumor size ≥ 14.25 mm and SUVmax ≥ 13.84. The gene discussed is FOLH1; the disease is neoplasm.