In this regard, reliable biomarkers could not only improve the accuracy of FMF diagnosis but also offer prognostic value and improve disease monitoring by providing insights into the underlying inflammatory pathways.Galectin-3, a member of the β-galactoside-binding lectin family, plays a multifaceted role in inflammation, apoptosis, fibrosis, immunity, and tumorigenesis [1,2,4]. Here, LGALS3 is linked to familial Mediterranean fever.