Novel biomarkers, including α9β1 integrin, lymphocyte subgroups, S100A8/A9 and S100A12 proteins, immature granulocytes, circulating endothelial microparticles, and asprosin have been investigated to predict FMF diagnosis and prognosis [3,16,21,22,23,24]. Here, S100A12 is linked to familial Mediterranean fever.