The association between biallelic causative variants in the TRIM36 (MIM*609317, TRIPARTITE MOTIF-CONTAINING PROTEIN 36) and in the NUAK2 (MIM*608131, NUAK FAMILY, SNF1-LIKE KINASE, 2) genes with anencephaly remains provisional, as it has been described in one family each [8,9]. Here, SIK1 is linked to anencephaly.