Galectin-3 is tightly regulated by several miRNAs—including miR-199a, miR-27b, miR-204-5p, miR-335, miR-1, miR-21, and miR-214—whose expression patterns correlate with pathological myocardial remodeling processes such as hypertrophy, ischemia/reperfusion injury, and HF. Here, LGALS3 is linked to hydrops fetalis.