Representative examples include ebselen, a glutathione peroxidase mimetic with neuroprotective activity comparable to donepezil; selenocysteine derivatives and selenofuranosides, which improved cognition and reduced neuropathology in AD mouse models; as well as sodium selenate, which attenuated tau hyperphosphorylation, albeit with reported dose-dependent neurotoxicity. Here, MAPT is linked to Alzheimer disease.