At the molecular level, hypercortisolemia causes dysregulation of the expression of factors such as Brain-Derived Neurotrophic Factor (BDNF), MAPK, cAMP Response Element-Binding Protein (CREB), and N-Methyl-D-Aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid (AMPA) receptors, which are essential for neuroplasticity and synaptic transmission. This evidence concerns the gene BDNF and adrenal gland hyperfunction.