This multicenter study (UK, Canada, and Ireland) analyzed the methylation status of previously identified DMGs (APC, GSTP1, HOXD3, KLK10, TBX15, and TGFB2) in urine collected from PCa patients (PCa n = 408 and BPH n = 182). Here, TGFB2 is linked to benign prostatic hyperplasia.