Likewise, another US study (training cohort PCa n = 344; mPCa n = 48) identified forty-two metastasis-associated CpGs (AUC 0.54 to 0.84) [98], eight of which were validated, and ALKBH5, FHAD1, KLHL8, and PI15 improved the Gleason-based risk stratification. This evidence concerns the gene PI15 and posterior cortical atrophy.