Clinically, USP44 methylation was absent in healthy donors and patients with localized PCa but detected in over half mPCa cases (qMSP; HD n = 0/10; early PCa n = 0/32; mPCa n = 20/39), where higher methylation levels were associated with reduced OS (p = 0.008) [126]. Here, USP44 is linked to posterior cortical atrophy.