A panel of seven DMCpGs (ACSS3, CRABP2, DHRS4L2, NKX2-6, SCGB3A1, HOXA7, and SERPIN1B) was progressively methylated from benign lesion to PCa (M450K BC; localized PCa n = 6 and adjacent n = 6) was later refined into smaller clinically adaptable panels [128]. Here, ACSS3 is linked to posterior cortical atrophy.