CCND1 and posterior cortical atrophy: (H450K BC; PCa patients n = 215 and controls n = 404) showed that hypermethylation of genes such as ADM, AEN, CCND1, CDC2, ORC2L RAP1GAP, RASSF1A, and TGFB1 was associated with a reduced risk of metastasis, whereas hypomethylation of CPN1, RARB, and VCAM1 conferred higher risks [96].