Using TCGA methylome data (PCa n = 423 and adjacent tissues n = 39), 1585 DMCpGs within promoters were identified [10] and a panel of 8 DMCpGs across six promoters (CBX5, CCDC8, CYBA, EFEMP1, KCNH2, and SOSTDC1) were selected by PAM analysis. This evidence concerns the gene SOSTDC1 and posterior cortical atrophy.