A larger FFPE study conducted in Germany and Belgium (high-risk PCa n = 218; BPH n = 42) confirmed that although a five DMG panel (qMSP; APC, CCND2, GSTP1, PTGS2, and RARB) displayed higher promoter methylation in high-risk PCa, only GSTP1 methylation remained significant in predicting metastasis or recurrence in multivariate analyses (HR = 3.7–4.3) [116]. Here, PTGS2 is linked to posterior cortical atrophy.