A validation cohort (qMSP; PCa/adjacent paired tissues n = 40) confirmed 9/12 DMGs, but only 5 (CCND2, RARB, RASSF1, SCGB3A1, and GSTP1) displayed high statistical significance (AUC = 0.89–0.95). Here, SCGB3A1 is linked to posterior cortical atrophy.