HAPLN3 and posterior cortical atrophy: After several validation rounds, a final three-gene panel (MSP-ddPCR; DOCK2, FBXO30 and HAPLN3) achieved high sensitivity and specificity in tissues (90–100%), but limited detection rates in a large plasma cohort (localized PCa n = 102, mPCa n = 65, BPH n = 61 and HDs n = 36).