GSTP1 and posterior cortical atrophy: Long-term patient follow-up studies (bisulfite sequencing, n = 15; median of 19.5 y) further confirmed that GSTP1 methylation arises early in low-Grade lesions (PCa n = 23, precancerous lesions n = 18, proliferative inflammatory atrophy n = 37) and expands across CpG islands with disease progression, correlating with recurrence and mortality.