PITX2 and posterior cortical atrophy: PITX2 methylation discriminated cancer from control tissues (p < 0.001), predicted recurrence (HR = 1.8; p < 0.05), and was associated with PFS in a German cohort (qMSP; PCa/adjacent paired tissues n = 24; PCa n = 300; PCa biopsies n = 32; BPH n = 31) [75].