Using a machine learning approach on TCGA database (DNA methylation and RNA-seq), Aldakheel et al. (2025) identified 684 DMGs and 691 DEGs between recurrence and non-recurrence groups, including 10 genes (AOX1, CCND1, COL5A3, FAMM71F2, FGFR1, SPIN2, SLC17A2, TNNI2, RNF169, and RREB1) with inverse methylation–expression relationships, implicating them in PCa relapse [86]. This evidence concerns the gene AOX1 and posterior cortical atrophy.