Testing 10 of these DMGs in tissues (qMSP; PCa n = 151, BPH n = 17 and control tissues n = 51) confirmed the significant hypermethylation of ADMATS12, NAALAD2, and PRKCB in PCa compared to BPH (p < 0.05). The gene discussed is PRKCB; the disease is benign prostatic hyperplasia.