An eight DMG panel tested in two American cohorts (pyrosequencing; PCa n = 11 and mPCa n = 23) [98] identified PI15 hypermethylation together with hypomethylation of ALKBH5, ATP11A, FHAD1, and KLH8 as predictors of metastatic disease. Here, PI15 is linked to posterior cortical atrophy.