SPAG4 and posterior cortical atrophy: An American multicenter study [24] also evaluated the methylation of six previously identified PCa-related DMGs (pyrosequencing; PCa n = 52, normal tissues n = 77), confirming the hypermethylation of CAV1, EVX1, PLAG2G16, and SPAG4 and hypomethylation of FGF1 and NCR2 in PCa relative to control tissues.