STAT3 and hepatocellular carcinoma: Histone deacetylase 8 (HDAC8)-mediated deacetylation at K62 promotes PKM2 nuclear translocation and CCND1 transcription via β-catenin, while also regulating its enzymatic activity and glucose metabolism [20], while Guanosine triphosphate binding protein 4 (GTPBP4) -induced SUMOylation facilitates dimer formation and nuclear entry, activating STAT3 signaling and epithelial–mesenchymal transition in HCC [21].