In addition to classical activators and inhibitors, membrane-bound protein A5 regulates hepatic macrophage polarization by directly blocking PKM2 Y105 phosphorylation and nuclear translocation, thereby attenuating HFD-induced NASH [39].Simvastatin sensitizes HCC cells to sorafenib by inhibiting HIF1-α/PPAR-γ/PKM2-mediated glycolysis. This evidence concerns the gene PKM and metabolic dysfunction-associated steatohepatitis.