HIF1A and hepatocellular carcinoma: In addition to classical activators and inhibitors, membrane-bound protein A5 regulates hepatic macrophage polarization by directly blocking PKM2 Y105 phosphorylation and nuclear translocation, thereby attenuating HFD-induced NASH [39].Simvastatin sensitizes HCC cells to sorafenib by inhibiting HIF1-α/PPAR-γ/PKM2-mediated glycolysis.