On one hand, it serves as a co-activator of β-catenin in human glioblastoma cells, promoting tumor metastasis; on the other hand, in hepatocellular carcinoma, it promotes the phosphorylation of histone H3 at T11, inducing the expression of PD-L1, and inhibiting the proliferation and function of T cells, leading to immune suppression in the tumor microenvironment [15]. Here, CD274 is linked to hepatocellular carcinoma.