PFKFB3 and breast cancer: In addition, PKM2 facilitates the co-recruitment of HIF-1α and the transcriptional co-activator p300 to the hypoxia response element (HRE) of the PFKFB3 gene, inducing chromatin structural alterations and enhancing PFKFB3 transcription—thereby promoting the proliferation of hypoxic breast cancer cells [86].