AARS1 and cancer: As the roles of AARS1/2 as lactate sensors and lactyltransferases are emerging, comprehensive lactylation profiling specifically for AARS1/AARS2 in cancers is worth exploring, which entails identifying all lactylated lysine sites on AARS1 and AARS2, respectively, and under varying metabolic conditions such as high/low lactate levels or hypoxia/normoxia.