During premature ovarian insufficiency, AARS2-mediated lactylation and inactivation of carnitine palmitoyl transferase 2 (CPT2) promoted granular cell proliferation and primordial follicle development by activating peroxisome proliferator-activated receptor γ (PPARγ)–follicle-stimulating hormone (FSH) synergy [9]. Here, CPT2 is linked to premature menopause.