Given the fact that many solid tumors feature a hypoxic state and high levels of lactate due to the Warburg effect, where cancer cells prefer glycolysis over OXPHOS [55,56], it is speculated that the overexpression of AARS2 in the context of hypoxia may inhibit OXPHOS and contribute to glycolysis in cancer cells, enabling cancer cells to adapt to hypoxia. This evidence concerns the gene AARS2 and cancer.