AARS1 and neoplasm: Analogously, in gastric cancer, AARS1 is translocated into the nucleus in response to intracellular lactate accumulation and directly lactylates the Yes1-associated transcriptional regulator (YAP) at the K90 residue and TEA domain transcription factor 1 (TEAD1) at the K108 residue, activating the expression of Hippo pathway target genes and thus promoting tumor cell proliferation [16].