HDAC2, as a deacetylase, promoted pancreatic ductal adenocarcinoma (PDAC) metastasis by sustaining the pro-survival program driven by receptor tyrosine kinases in undifferentiated mesenchymal PDAC cells and protecting mesenchymal PDAC cells from the tumor-suppressive effects of the transforming growth factor β (TGFβ) pathway [70]. Here, HDAC2 is linked to neoplasm.