LRRK2 and Alzheimer disease: In order to dissect the impact of LRRK2-mediated neuroinflammation on neurons, we implemented RNA-Seq analysis on hiPSC-derived dopaminergic (DA) neurons exposed to α-syn pff-inflamed glial medium (context related to PD) and on hiPSC-derived cholinergic (CHOL) neurons exposed to Aβ1–42 fibril-inflamed glial medium (context related to AD), where glial cells were activated in the presence or absence of LRRK2 kinase inhibitors MLi2 and PF.