In this study, to understand how LRRK2-mediated neuroinflammation impacts neuronal networks in PD and AD, we set up a cellular model with hiPSC-derived DA or CHOL neurons exposed to α-syn pff- or Aβ1–42 fibril-inflamed glial medium for several days, and we created a neuronal RNA-Seq profile. The gene discussed is LRRK2; the disease is Parkinson disease.