SSc patients with CRS had statistically significant higher mean NT-proBNP (12.36 ± 8.15 pg/mL vs. 5.79 ± 6.83 pg/mL, p < 0.05), mean galectin-3 (7349.69 ± 2088.51 pg/mL vs. 6049.76 ± 2411.23 pg/mL, p < 0.05), mean suPAR (5.35 ± 1.26 ng/mL vs. 4.70 ± 1.83 ng/mL, p < 0.05), mean sNGAL (49.82 ± 12.52 ng/mL vs. 40.57 ± 23.69 ng/mL, p < 0.05), mean uNGAL levels (115.40 ± 12.95 ng/mL vs. 104.95 ± 23.83 ng/mL, p < 0.05) and mean RRI (0.72 ± 0.05 vs. 0.69 ± 0.09, p < 0.05) compared to SSc patients without CRS. This evidence concerns the gene LGALS3 and congenital rubella syndrome.