Specifically, as lung cancer remains the leading cause of cancer-related deaths in the United States, research by Subhadeep Das and colleagues demonstrated that the anticancer compound supinoxin suppresses small-cell lung cancer proliferation and tumor growth by targeting DDX5 to inhibit mitochondrial gene expression and disrupt mitochondrial respiration, thereby depriving tumor cells of energy and exerting an antitumor effect [4,5]. Here, DDX5 is linked to neoplasm.