CR1 and Alzheimer disease: Besides that, the functional annotation of these risk loci indicates that neuroinflammatory (complement receptor 1, CR1) cholesterol and lipid metabolism dysregulation (complement regulators clusterin, CLU) [14], endosomal vesicle recycling pathways (BIN1, PICALM, CD2AP, and EPHA1), and others (PLD3) contribute to the pathogenesis of AD.