MAPT and Alzheimer disease: The neuropathological hallmarks of AD include the abnormal accumulation and aggregation of amyloid-β (Aβ) peptides in the extracellular compartment of the CNS forming so-called senile plaques (SPs), alongside the intracellular deposition of neurofibrillary tangles (NFTs), containing hyperphosphorylated tau (p-tau) protein [156].