In particular, phosphorylation of Drp1 at Serine 616 (S616) activates Drp1 and results in mitochondrial fragmentation, and is possibly involved in neuronal death [67], suggesting that the increased level of phospho-Drp1 correlates with the mitochondrial morphological changes in the hippocampus and the cognitive decline observed with aging [46]. This evidence concerns the gene DNM1L and Mental deterioration.