ITGA2 and acute lymphoblastic leukemia: High ITGA2 expression is associated with lower complete remission rates and shorter overall survival in AML patients, with levels dropping in remission and rising at relapse, indicating its role as a poor prognostic marker; additionally, α2β1-mediated adhesion to collagen I in T-ALL cells reduces doxorubicin-induced apoptosis, contributing to chemo-resistance [34].