It is reported that ITGA2 is upregulated in chemo-resistant gastric cancer (GC) cells and correlates with poor prognosis, while its knockdown restores chemo-sensitivity by downregulating MAPK/ERK signaling and EMT; additionally, miR-135b-5p directly targets ITGA2, reducing chemo-resistance and highlighting the miR-135b-5p/ITGA2 axis as a potential diagnostic and therapeutic target in GC [31]. Here, ITGA2 is linked to gastric cancer.