For example, Zhou W et al. in their study have reported that FTO expression is upregulated in the AML1::ETO subtype of AML in adult patients and have demonstrated that AML1::ETO upregulates FTO mechanistically, through inhibiting the transcriptional repression of FTO mediated by transcription factor PU.1. This evidence concerns the gene RUNX1T1 and acute myeloid leukemia.