NFKB1 and acute respiratory distress syndrome: While the phospho-p38 and total p38 balance is only modestly (but significantly) affected by ODSH, we believe that, overall, these findings suggest that ODSH may attenuate ALI in mice, at least in part, via attenuation of LPS-driven expression and activation of pro-inflammatory pathways involved in NF-κB and p38 signaling axes.