In a dry AMD model, modulation of σ2R/TMEM97 rescued oxidative-stress- and amyloid-beta oligomer (AβO)-induced deficits in the homeostatic recycling of photoreceptor outer segments (POSs) by the RPE [30]; however, how this modulation affects σ2R/TMEM97 activity and downstream signaling remains unknown. Here, TMEM97 is linked to dry age related macular degeneration.