In addition, with future research to better understand the complex, and potentially cell-type-specific, roles of σ2R/TMEM97 in the RPE and retina, using genetic approaches targeting σ2R/TMEM97, such as adeno-associated virus (AAV)-mediated gene delivery or gene editing technologies, may provide alternative strategies for developing new treatments for retinal diseases. The gene discussed is TMEM97; the disease is Abnormal retinal morphology.