TMEM97 and breast carcinoma: In MDA-MB-23 breast cancer cells, a triple-negative breast cancer cell line, σ2R/TMEM97 overexpression decreases the inhibitory interaction between cholesterol and SOCE calcium channel Orai1 (ORAI calcium release-activated calcium modulator 1), thus enhancing SOCE; conversely, silencing σ2R/TMEM97 increases the inhibitory interaction and suppresses SOCE [22].