ADAM17 and familial dilated cardiomyopathy: In line with this, genetic ablation of ADAM17—a regulator of PANoptosis—has been reported to attenuate cardiomyocyte apoptosis, improve ventricular remodeling, and preserve cardiac function in DCM mice, potentially via suppression of ACE2, activation of the AMPK pathway, and TFEB-mediated enhancement of autophagy [36,37].