In agreement, qRT-PCR analysis revealed that mRNA levels of cGAS, STING, TANK-binding kinase 1 (TBK1), and interferon regulatory factor 3 (IRF3) were considerably elevated in the DCM group relative to controls, but were effectively suppressed by exercise training, and HIIT exerted the strongest inhibitory effect (Figure 6B–E). The gene discussed is IRF3; the disease is familial dilated cardiomyopathy.