GSTM1 and Parkinson disease: Gene enrichment analysis further revealed that the overexpression of Hb led to significant alterations in key pathways related to oxygen homeostasis, oxidative phosphorylation, oxidative stress, and iron metabolism in dopaminergic neurons, all of which are closely related to the pathogenesis of PD, thus suggesting that Hb may play a protective role in the pathology of PD [124,125].