Researchers demonstrated that M1-polarized macrophages could release C-X-C Motif Chemokine Ligand 10 (CXCL10),which is able to regulate the recruitment of immune cells, antiviral defense and tumor immunity by promoting the migration of gut-derived inflammatory T cells to pancreatic islets through binding to CXCR3 (the homologous receptor expressed on T cells) [46,47]. This evidence concerns the gene CXCL10 and neoplasm.