MLKL and neoplasm: In pancreatic cancer, Liao et al. found that Mixed Lineage Kinase Domain-like Protein (MLKL) mediating necroptosis not only upregulated CD47 expression on tumor cell surfaces to inhibit macrophage-mediated phagocytosis, but also promoted epithelial–mesenchymal transition and endothelial adhesion through the release of CXCL8 and activation of the CXCR1/2 signaling axis [51].