In this context, we investigated the association between PD and five single-nucleotide polymorphisms (SNPs) located in NER pathway genes—ERCC1 (rs11615), ERCC2 (rs13181), XPA (rs1800975), XPC (rs2228001), and XPF (rs1799801)—in a northern Mexican mestizo population. The gene discussed is XPC; the disease is Parkinson disease.