S100B and early-onset autosomal dominant Alzheimer disease: Moreover, Nef has been analyzed in postmortem brain samples from subjects with HAND, and it was found to be correlated with the abundance of the lipid rafts marker flotillin 1 and with that of Tau protein phosphorylated on threonine 217 (p-Tau217), an early marker of Alzheimer’s disease, and with HAND severity [65].