Interestingly, it has been shown that lncRNA AK006025 was implicated in the regulation of the Nef-induced expression of C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, and C-X-C motif chemokine ligand 11 (CXCL11) by interacting with nuclear factor (NF)-κB p65 and CREB-binding protein (CBP)/P300, potentially contributing to neuroinflammation and pathogenesis of HAND [49]. Here, S100B is linked to HIV-associated neurocognitive disorder.