In vitro studies demonstrate that peripheral blood mononuclear cells from MuSK-MG patients secrete increased levels of Th1 (IFN-γ), Th17 (IL-17A), and Tfh (IL-21) cytokines upon stimulation, indicating a heightened pro-inflammatory and B cell-helping environment compared to healthy controls and AChR-MG patients [76,77]. This evidence concerns the gene IL21 and myasthenia gravis.