ACE and Borderline personality disorder: Thus, while our data do not suggest a direct association of ACE and PRDM8 DNAm, the broader relationship between pre- and postnatal trauma, PRDM8 epigenetic regulation, and BPD psychopathology remains to be further elucidated, especially as the lack of prenatal trauma data in our sample hinders the decoding of effects of pre- vs. postnatal trauma on PRDM8 DNAm.