Furthermore, data on prenatal trauma as well as comorbidities such as PTSD or major depressive disorder were not available, which made disentanglement of pre- and postnatal adversity impossible and may have mediated the association between BPD and DNAm in PRDM8. Lastly, gene and protein expression levels were not assessed, which hinders the interpretation of possible functional consequences of the observed DNAm patterns. The gene discussed is PRDM8; the disease is major depressive disorder.