SCAPER (S-phase cyclin A-associated protein in the endoplasmic reticulum) is mainly involved in nucleic acid binding, which has been reported to be associated with nonsyndromic intellectual disability [93] and retinal disease [94] in humans, male sterility and reduced female fertility in mice [95], sperm motility in Holstein cattle [96], adaptation in the cattle [97], growth and nervous system in goats [98], and as a potential deleterious gene selected in Tibetan pigs [99]. The gene discussed is SCAPER; the disease is Intellectual disability.