Dou et al. reported a greater predictive accuracy of 48-h HBP (AUC: 0.82) change than baseline HBP (0.79), PCT (0.72), lactate (0.71), CRP (0.65), and HBPc-24 (0.62) hours for the prediction of 30-day mortality in critically ill patients with sepsis in the ICU [13]. The gene discussed is CRP; the disease is Sepsis.