The authors demonstrated tumor-specific cytotoxicity when co-culturing allogeneic CAR-T lymphocytes with gene knockout and the Raji cell line: secretion of the pro-inflammatory cytokines IFN-γ and TNF-α was comparable in CAR-T lymphocytes with and without gene editing, while in some cases allogeneic CAR-T cells produced more pro-inflammatory cytokines. Here, IFNG is linked to neoplasm.