ANG and idiopathic pulmonary fibrosis: On the other hand, the upregulation of the Mas receptor in IPF may reflect an attempt to counteract fibrotic remodeling via the Ang-(1-7)/Mas axis [41], whereas the higher expression of MrgD receptor in control lungs—associated with Alamandine’s antifibrotic and anti-inflammatory actions—suggests a loss of this protective signaling in disease.