IL6 and obesity due to melanocortin 4 receptor deficiency: Importantly, He et al. showed that elevated IL-6 levels in patients with TRS compared to partially responsive schizophrenia (PRS) patients may be indirectly related to the presence of comorbid obesity, and the inflammatory changes observed in schizophrenic patients may originate from excess adipose tissue, particularly in the male TRS subgroup where a positive correlation between IL-6 levels and BMI was found [180].