Interestingly, Soldevila-Matías et al. demonstrated that the combination of baseline IL-6 levels with markers of cardiometabolic activity such as low-density lipoprotein (LDL), systolic blood pressure (SBP), and insulin significantly predicted changes in global cognitive score (GCS) over time in the entire study group, which also included individuals with SCZ and coexisting obesity [179]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.