Immunological evaluation of PLHIV revealed a mean CD4 + lymphocyte count of 621.12 ± 593 cells/mm3 in PLHIV and osteopenia/osteopororsis and a mean CD4 + lymphocyte count of 704.93 ± 727 cells/mm3 in PLHIV with normal BMD, with no statistically significant differences between these two groups (p = 0.640, Mann–Whitney U test). This evidence concerns the gene CD4 and Osteopenia.