HCLS1 was engaged in functional pathways such as ‘leukocyte mediated cytotoxicity (GO)’, ‘regulation of lymphocyte mediated immunity (GO)’, ‘adaptive immune response (GO)’, ‘primary immunodeficiency-Homo sapiens (human) (KEGG)’, ‘type I diabetes mellitus-Homo sapiens (human) (KEGG)’, ‘systemic lupus erythematosus-Homo sapiens (human) (KEGG)’ (Figure 3G,H). Here, HCLS1 is linked to inborn error of immunity.