Especially regarding IDH-wildtype and IDH-mutant gliomas, DL algorithms are becoming increasingly capable of identifying their status, as the former tend to demonstrate more aggressive features such as solid enhancing regions and necrotic core formation, while the latter often present with less prominent contrast enhancement and diffuse oedema on MRI, sometimes mimicking low-grade gliomas [45,46]. Here, IDH1 is linked to central nervous system cancer.