TP53 and central nervous system cancer: Specific imaging phenotypes including tumor texture patterns, apparent diffusion coefficient (ADC) values and the degree of contrast enhancement have been found to correlate with molecular subtypes; features indicative of a more aggressive tumor phenotype (e.g., increased necrosis, irregular vascular patterns) often correspond to gliomas with genetic alterations in key oncogenes and tumor-suppressor genes, such as the isocitrate dehydrogenase (IDH)-status, tumor protein 53 (TP53) mutations, and EGFR amplification [44].