We previously reported that SAHA, combined with the DNA-demethylating agent 5-AZA, enhanced p53 acetylation, upregulated p21, and impaired the survival of pancreatic cancer cells by upregulating metallothionein 2, which can sequester zinc ions required for the activity of zinc-dependent HDACs [8]. The gene discussed is MT2A; the disease is familial pancreatic carcinoma.