Interestingly, contrary to those observed previously by our research in adipose tissue of patients with obesity and other metabolic diseases, in blood samples we did not observe significant correlations between clinical parameters and CpG methylation within the AIM2, FAM134C, GNAS, LCLAT1, and ZNF714 [12,13,14]. This evidence concerns the gene ZNF714 and obesity due to melanocortin 4 receptor deficiency.