NFE2L2 and schizophrenia: There are studies that show that increases in the activity levels of anti-inflammatory factors such as nuclear factor-erythroid-2-related factor 2 (Nrf2) and neuronal receptor tyrosine kinase-2 (TrkB), substances that reduce neuroinflammation, could reduce the risk of juvenile prodromal syndromes making the transition to schizophrenia [108].