For PD-L1, we analyzed two SNPs within its 3’ untranslated region (3’UTR) of the CD274 gene on chromosome 9p24, a key regulatory region for mRNA stability and translation: rs4143815, which disrupts a binding site for the tumor suppressor miR-570, up-regulating PD-L1 expression and increasing the risk of multiple malignant disorders [18,19], and rs2297136, which has been associated with cancer prognosis and is predicted to affect miRNA binding [20]. The gene discussed is CD274; the disease is cancer.