Tumor-suppressive miRNAs converge on glycolysis by directly repressing rate-limiting nodes—HK2 (miR-125a/miR-885-5p), PFKFB3/GLUT1/c-Myc axis (miR-192-5p), and HIF-1α (miR-199a-5p/miR-3662), reducing glucose influx and lactate production and favoring mitochondrial oxidation. This evidence concerns the gene HK2 and neoplasm.