Bioinformatics analyses of cancer-associated fibroblasts (CAFs) have identified ten CAF-related genes—ANGPTL4, CPNE8, CST2, HTR1F, IL1RAP, NR1D1, NTAN1, OLFML2B, TMEM259, and VTN—that exhibit strong prognostic significance for gastric cancer (GC) and provide substantial value in assessing patient survival outcomes [13]. Here, TMEM259 is linked to gastric cancer.