Following a comprehensive literature search for articles investigating the contribution of the LPCAT1 (rs9728; c.*1668T>C) variant to the susceptibility of NRDS among different ethnic populations, this retrospective research was the outstanding study that assessed the association of this noncoding variant within the 3′UTR with the susceptibility and severity of respiratory distress syndrome among Egyptian preterm neonates. Here, LPCAT1 is linked to newborn respiratory distress syndrome.