FOXP3 and neoplasm: We added spatial dimension to our data by separately assessing the infiltration by CD4+/FOXP3+ TILs, which are in contact with neoplastic cells (designated as intratumoral (IT) subpopulations) and by CD4+/FOXP3+ TILs infiltrating tumor stroma without being in direct contact with a malignant population (designated as stromal (ST) subpopulations) (Figure 1 and Figure 2).