Another study showed that naïve CD4 cells are more prevalent in cervical carcinoma than in precancerous low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL), and that FOXP3-expressing Tregs are more abundant in cervical carcinoma but are in a state of exhaustion [60]. This evidence concerns the gene FOXP3 and squamous cell intraepithelial neoplasia.