For example, IL-1β can induce IL-6 and IL-8, which recruit and polarize myeloid cells that further secrete pro-tumor cytokines, thereby sustaining a feed-forward inflammatory circuit; conversely, blockade of IL-1β or IL-6 in preclinical models reduces metastatic seeding and restores cytotoxic T-cell activity. This evidence concerns the gene IL1B and neoplasm.