Lymph node-positivity, disease-free survival less than 12 months, ≥1 CLM, and longitudinal diameter of the larger tumor > 3 cm (instead of 5 cm for surgical CRS) constituted the clinical factors and each one counts as one point towards the mCRS; CEA level was not included at that time point due to lack of the corresponding information. Here, CEACAM5 is linked to neoplasm.